Carboxylic acid salts
Apexbio Technology LLC AVE 0991 sodium salt 306288-04-0 50mg
AVE 0991 sodium salt (CAS 306288-04-0) is a synthetic non-peptide agonist of the angiotensin-(1-7) receptor Mas Acting as a functional mimic of angiotensin-(1-7) AVE 0991 competitively binds to endothelial cell membranes with an IC50 of 21 35 nM in bovine aortic endothelial cells In vitro treatment with AVE 0991 promotes nitric oxide release to levels significantly greater than angiotensin-(1-7) In vivo AVE 0991 reduces urine volume and increases urine osmolality in mice effects reversed by angiotensin II antagonists indicating receptor specificity It also inhibits atherogenesis in ApoE knockout mice supporting its application in cardiovascular and renal research
AdipoGen R-3-Hydroxyisobutyric acid Na
Chemical. CAS 1228078-57-6. Formula C4H7O3 . Na. MW 103.1 . 23.0. Synthetic. Intermediate formed in the valine catabolism. It is a reactant of the enzymes involved in branched chain amino acid metabolism 3-hydroxyisobutyrate dehydrogenase and 3-hydroxyisobutyryl-CoA hydrolase and it was found to have increased concentrations in MS patient metabolic profiles. This compound may be used to study the distribution, characterization and kinetics of these enzymes. Shown to inhibit key enzymes of the energy metabolism.
AdipoGen D-Luciferin potassium salt
Chemical. CAS 115144-35-9. Formula C11H7KN2O3S2. MW 318.41. D-Luciferin is the most popular and versatile bioluminescent substrate. Firefly luciferase produces light by the ATP-dependent oxidation Mg2 as cofactor of luciferin. It emits a characteristic yellow-green emission in the presence of oxygen, which shifts to red light in vivo. The 560nm chemiluminescence from this reaction peaks within seconds, with light output that is proportional to luciferase activity when luciferin and ATP are present in excess. Firefly luciferase has long been conjugated to antibodies and used as a label in immunoassays using luciferin as the substrate for detection. One particular advantage to the enzyme is that there is low endogenous luciferase activity in mammalian tissues besides its high sensitivity. Through the utilization of ATP, the reaction can be further used to indicate the presence of energy or life in order to function as a life-death stain.
Selleck Chemical LLC Taurocholic acid sodium salt
Taurocholic acid sodium salt (Sodium Taurocholate TANa) is a sodium salt of taurocholic acid and occurs in the bile of mammals Taurocholic acid is used as a cholagogue and choleretic
AdipoGen D Galacturonic acid Na
Chemical. CAS 14984-39-5. Formula C6H9NaO7. MW 216.12. Synthetic. A sugar acid sodium salt preparation.
eMolecules Iron(II) Gluconate Hydrate | 22830-45-1 | MFCD04037236 | 25g
Ambeed | Iron(II) Gluconate Hydrate | 25g | 600848990 | A851847 | | 22830-45-1 | MFCD04037236 | 464.154 | C12H24FeO15
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![Medchemexpress LLC 2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]i | 2080306-23-4 | ≥98.0% | 429.5 Da | C25H23N3O4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241410.png-250.jpg)
Medchemexpress LLC 2-(2,3-dihydro-1,3,6-trimethyl-2-oxo-1H-benzimidazol-5-yl)-6-(3-hydroxypropyl)-1H-benz[de]i | 2080306-23-4 | ≥98.0% | 429.5 Da | C25H23N3O4 | 100 MG
BAY-299 is a small-molecule chemical probe that potently inhibits bromodomain-containing proteins, primarily BRPF2 (BRD1) and TAF1 family bromodomains. It is intended for research use in biochemical and cellular assays to probe bromodomain function, validate targets, and investigate chromatin-mediated transcriptional regulation. The compound is supplied as a solid with high purity suitable for laboratory studies.
- Potent biochemical inhibition of BRPF2 and TAF1 family bromodomains.
- Reported IC50 values: BRPF2 BD - 67 nM; TAF1 BD2 - 8 nM; TAF1L BD2 - 106 nM.
- Suitable for target validation and mechanistic studies in epigenetics.
- High purity (≥98%) for reliable assay performance.
- Molecular weight 429.5 Da and chemical formula C25H23N3O4.
- Supplied as a solid for routine laboratory handling.
AdipoGen DL-3-Hydroxybutyric acid Na
Chemical. CAS 150-83-4. Formula C4H7NaO3. MW 126.1. Synthetic. Neuroprotective compound in experimental models of neurodegenerative diseases. Shown to be oxidized as an energetic substrate in the brain during starvation. May inhibit brain glucose oxidation, which may account for the suppression of hepatic glucose production observed after administration of ketone bodies in humans.
Medchemexpress LLC DG013A (formate) | 00-00-0 | 99.6% | C27H37N4O4P.2/5CH2O2 | 10MG
DG013A (formate) is a phosphinic acid tripeptide-mimetic inhibitor for research use targeting endoplasmic reticulum aminopeptidases ERAP1 and ERAP2. It is supplied as a powder with molecular formula C27H37N4O4P·2/5CH2O2 and molecular weight 530.99; reported potency values are ERAP1 IC50 = 33 nM and ERAP2 IC50 = 11 nM.
- Phosphinic acid tripeptide-mimetic inhibitor.
- Potent ERAP1 and ERAP2 inhibition (IC50 33 nM and 11 nM).
- High purity (99.6% by LCMS).
- Powder form for easy handling and storage.
- Stable as powder at -20°C for up to 3 years.
- In-solvent stability: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC 5-bromouridine 5'-triphosphate sodium salt | 161848-60-8 | MFCD00274403 | 98.0% | 563.04 g/mol | C9H14BrN2O15P3.xNa | 1 MG
5-BrUTP sodium salt is a brominated uridine triphosphate used as a nucleotide analog to label RNA in transcription assays. It can be enzymatically incorporated into nascent RNA during in vitro transcription or cellular labeling, and incorporated BrUTP residues are detected immunologically to quantify or visualize newly synthesized RNA.
- Enables labeling of newly synthesized RNA for transcription analysis.
- Detectable by anti-BrdU antibodies for immunodetection.
- Brominated uridine analog compatible with enzymatic incorporation during transcription.
- Sodium salt form offers improved aqueous solubility for biochemical workflows.
- High purity (98.0%) suitable for sensitive biochemical assays.
- Available in multiple pack sizes to support small- and large-scale experiments.
Medchemexpress LLC 6-(3-hydroxypropyl)-2-(trimethyl-2-oxo-2,3-dihydro-benzimidazol-5-yl)-benzoisoquinoline-1,3-dione | 2080306-23-4 | MFCD30480933 | 99.4% | 429.47 g·mol⁻¹ | C25H23N3O4 | 50 MG
BAY-299 is a benzoisoquinolinedione chemical probe originally described by Bayer that potently inhibits the bromodomain-containing proteins BRPF2 (BRD1) and the second bromodomain of TAF1 and TAF1L. It is used in biochemical, structural, and cellular studies to probe bromodomain function and selectivity, with reported biochemical IC50s in the low-nanomolar range and validated activity in cell-based assays.